EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
ジャーナル・号・ページ	J. Med. Chem., Vol. 51, Page 3804-3813, Year 2008
掲載日	2008年2月26日 (構造データの登録日)
著者	Sarver, R.W. / Bills, E. / Bolton, G. / Bratton, L.D. / Caspers, N.L. / Dunbar, J.B. / Harris, M.S. / Hutchings, R.H. / Kennedy, R.M. / Larsen, S.D. ...Sarver, R.W. / Bills, E. / Bolton, G. / Bratton, L.D. / Caspers, N.L. / Dunbar, J.B. / Harris, M.S. / Hutchings, R.H. / Kennedy, R.M. / Larsen, S.D. / Pavlovsky, A. / Pfefferkorn, J.A. / Bainbridge, G.
リンク	J. Med. Chem. / PubMed:18540668
手法	X線回折
解像度	1.7 - 2.4 Å
構造データ	PDB-3cct: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-3ccw: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3ccz: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3cd0: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3cd5: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.39 Å PDB-3cd7: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-3cda: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-3cdb: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å
化合物	ChemComp-3HI: (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid / o-ヒドロキシアトルバスタチン ChemComp-HOH: WATER / 水 ChemComp-4HI: (3R,5R)-7-[4-(benzylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-5HI: (3R,5R)-7-[2-(4-fluorophenyl)-4-{[(1S)-2-hydroxy-1-phenylethyl]carbamoyl}-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid ChemComp-6HI: (3R,5R)-7-{2-[(4-fluorobenzyl)carbamoyl]-4-(4-fluorophenyl)-1-(1-methylethyl)-1H-imidazol-5-yl}-3,5-dihydroxyheptanoic acid ChemComp-7HI: (3R,5R)-7-[3-(biphenyl-4-ylcarbamoyl)-2-ethyl-5,6,7,8-tetrahydrocyclohepta[b]pyrrol-1(4H)-yl]-3,5-dihydroxyheptanoic acid ChemComp-882: (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID ChemComp-8HI: (3R,5R)-7-{3-(4-fluorophenyl)-1-(1-methylethyl)-4-phenyl-5-[(4-sulfamoylphenyl)carbamoyl]-1H-pyrrol-2-yl}-3,5-dihydroxyheptanoic acid ChemComp-9HI: (3R,5R)-7-{3-[(4-carbamoylphenyl)sulfamoyl]-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl}-3,5-dihydroxyheptanoic acid
由来	homo sapiens (ヒト)
キーワード	OXIDOREDUCTASE (酸化還元酵素) / CHOLESTEROL BIOSYNTHESIS / HMG-COA (ヒドロキシメチルグルタリルCoA) / NADPH (ニコチンアミドアデニンジヌクレオチドリン酸) / STATIN (スタチン) / Alternative splicing (選択的スプライシング) / Endoplasmic reticulum (小胞体) / Glycoprotein (糖タンパク質) / Lipid synthesis (脂質代謝) / Membrane (生体膜) / Peroxisome (ペルオキシソーム) / Polymorphism / Steroid biosynthesis (ステロイド) / Transmembrane (膜貫通型タンパク質)