タイトル | Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. |
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ジャーナル・号・ページ | Structure, Vol. 16, Page 1714-1723, Year 2008 |
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掲載日 | 2007年10月16日 (構造データの登録日) |
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著者 | Wu, Y.H. / Ko, T.P. / Guo, R.T. / Hu, S.M. / Chuang, L.M. / Wang, A.H.J. |
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リンク | Structure / PubMed:19000823 |
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手法 | X線回折 |
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解像度 | 1.63 - 2 Å |
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構造データ | PDB-2zb3: Crystal structure of mouse 15-ketoprostaglandin delta-13-reductase in complex with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2zb4: Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP and 15-keto-PGE2 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-2zb7: Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADPH and nicotinamide 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2zb8: Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP and indomethacin 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-NDP: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / NADPH
ChemComp-NAP: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
ChemComp-5OP: (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID
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由来 | ![](img/tx_mammal.gif) mus musculus (ハツカネズミ) homo sapiens (ヒト)
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キーワード | OXIDOREDUCTASE / Rossmann fold / Alternative splicing / Cytoplasm / NADP |
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