タイトル | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 1966-, Year 2010 |
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掲載日 | 2009年9月2日 (構造データの登録日) |
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著者 | Jiracek, J. / Zakova, L. / Antolikova, E. / Watson, C.J. / Turkenburg, J.P. / Dodson, G.G. / Brzozowski, A.M. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:20133841 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.59 Å |
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構造データ | PDB-2wru: Semi-synthetic highly active analogue of human insulin NMeAlaB26-DTI- NH2 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-2wrv: Semi-synthetic highly active analogue of human insulin NMeHisB26-DTI- NH2 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-2wrw: Semi-synthetic highly active analogue of human insulin D-ProB26-DTI- NH2 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-2wrx: Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-2ws0: Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2ws1: Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-2ws4: Semi-synthetic analogue of human insulin ProB26-DTI in monomer form 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2ws6: Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-2ws7: Semi-synthetic analogue of human insulin ProB26-DTI 手法: X-RAY DIFFRACTION / 解像度: 2.59 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
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キーワード | HORMONE / CARBOHYDRATE METABOLISM / GLUCOSE METABOLISM / ANALOGUE / DIABETES MELLITUS / INSULIN |
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