+検索条件
-Structure paper
タイトル | Structures of translationally inactive mammalian ribosomes. |
---|---|
ジャーナル・号・ページ | Elife, Vol. 7, Year 2018 |
掲載日 | 2018年10月24日 |
著者 | Alan Brown / Matthew R Baird / Matthew Cj Yip / Jason Murray / Sichen Shao / |
PubMed 要旨 | The cellular levels and activities of ribosomes directly regulate gene expression during numerous physiological processes. The mechanisms that globally repress translation are incompletely understood. ...The cellular levels and activities of ribosomes directly regulate gene expression during numerous physiological processes. The mechanisms that globally repress translation are incompletely understood. Here, we use electron cryomicroscopy to analyze inactive ribosomes isolated from mammalian reticulocytes, the penultimate stage of red blood cell differentiation. We identify two types of ribosomes that are translationally repressed by protein interactions. The first comprises ribosomes sequestered with elongation factor 2 (eEF2) by SERPINE mRNA binding protein 1 (SERBP1) occupying the ribosomal mRNA entrance channel. The second type are translationally repressed by a novel ribosome-binding protein, interferon-related developmental regulator 2 (IFRD2), which spans the P and E sites and inserts a C-terminal helix into the mRNA exit channel to preclude translation. IFRD2 binds ribosomes with a tRNA occupying a noncanonical binding site, the 'Z site', on the ribosome. These structures provide functional insights into how ribosomal interactions may suppress translation to regulate gene expression. |
リンク | Elife / PubMed:30355441 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.3 - 5.9 Å |
構造データ | EMDB-9234: EMDB-9235: EMDB-9236: EMDB-9237, PDB-6mtb: EMDB-9239, PDB-6mtc: EMDB-9240, PDB-6mtd: EMDB-9241: |
化合物 | ChemComp-MG: ChemComp-ZN: ChemComp-GDP: |
由来 |
|
キーワード | RIBOSOME / translation |