タイトル | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2023年5月5日 (構造データの登録日) |
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著者 | Huang Y / Lu W / Du J |
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リンク | PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.52 - 4.14 Å |
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構造データ | EMDB-40727, PDB-8srd: Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state 手法: EM (単粒子) / 解像度: 2.91 Å EMDB-40728, PDB-8sre: Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state 手法: EM (単粒子) / 解像度: 2.52 Å EMDB-40729, PDB-8srf: Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state 手法: EM (単粒子) / 解像度: 2.52 Å EMDB-40730, PDB-8srg: Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate 手法: EM (単粒子) / 解像度: 3.03 Å EMDB-40731, PDB-8srh: Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state 手法: EM (単粒子) / 解像度: 3.79 Å EMDB-40732, PDB-8sri: Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state 手法: EM (単粒子) / 解像度: 2.73 Å EMDB-40733, PDB-8srj: Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of EDTA, apo state 手法: EM (単粒子) / 解像度: 3.74 Å EMDB-40734, PDB-8srk: Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of Ca and ADP-ribose 手法: EM (単粒子) / 解像度: 4.14 Å |
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化合物 | |
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由来 | salpingoeca rosetta (真核生物)
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キーワード | MEMBRANE PROTEIN / TRPM2 Chanzyme / Channel-enzyme |
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