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-Structure paper
タイトル | Novel Inter-Subunit Contacts in Barley Stripe Mosaic Virus Revealed by Cryo-Electron Microscopy. |
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ジャーナル・号・ページ | Structure, Vol. 23, Issue 10, Page 1815-1826, Year 2015 |
掲載日 | 2015年10月6日 |
著者 | Daniel Kofi Clare / Eugenia V Pechnikova / Eugene V Skurat / Valentin V Makarov / Olga S Sokolova / Andrey G Solovyev / Elena V Orlova / |
PubMed 要旨 | Barley stripe mosaic virus (BSMV, genus Hordeivirus) is a rod-shaped single-stranded RNA virus similar to viruses of the structurally characterized and well-studied genus Tobamovirus. Here we report ...Barley stripe mosaic virus (BSMV, genus Hordeivirus) is a rod-shaped single-stranded RNA virus similar to viruses of the structurally characterized and well-studied genus Tobamovirus. Here we report the first high-resolution structure of BSMV at 4.1 Å obtained by cryo-electron microscopy. We discovered that BSMV forms two types of virion that differ in the number of coat protein (CP) subunits per turn and interactions between the CP subunits. While BSMV and tobacco mosaic virus CP subunits have a similar fold and interact with RNA using conserved residues, the axial contacts between the CP of these two viral groups are considerably different. BSMV CP subunits lack substantial axial contacts and are held together by a previously unobserved lateral contact formed at the virion surface via an interacting loop, which protrudes from the CP hydrophobic core to the adjacent CP subunit. These data provide an insight into diversity in structural organization of helical viruses. |
リンク | Structure / PubMed:26278173 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 4.1 - 5.8 Å |
構造データ | EMDB-3073, PDB-5a79: EMDB-3074, PDB-5a7a: EMDB-3077: EMDB-3078: |
由来 |
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キーワード | VIRUS / BSMV / HELICAL / CRYO-EM / IMAGE PROCESSING / MSA |