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-Structure paper
タイトル | Structure and immune recognition of the porcine epidemic diarrhea virus spike protein. |
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ジャーナル・号・ページ | Structure, Vol. 29, Issue 4, Page 385-392.e5, Year 2021 |
掲載日 | 2021年4月1日 |
著者 | Robert N Kirchdoerfer / Mahesh Bhandari / Olnita Martini / Leigh M Sewall / Sandhya Bangaru / Kyoung-Jin Yoon / Andrew B Ward / |
PubMed 要旨 | Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus responsible for significant morbidity and mortality in pigs. A key determinant of viral tropism and entry, the PEDV spike protein is a ...Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus responsible for significant morbidity and mortality in pigs. A key determinant of viral tropism and entry, the PEDV spike protein is a key target for the host antibody response and a good candidate for a protein-based vaccine immunogen. We used electron microscopy to evaluate the PEDV spike structure, as well as pig polyclonal antibody responses to viral infection. The structure of the PEDV spike reveals a configuration similar to that of HuCoV-NL63. Several PEDV protein-protein interfaces are mediated by non-protein components, including a glycan at Asn264 and two bound palmitoleic acid molecules. The polyclonal antibody response to PEDV infection shows a dominance of epitopes in the S1 region. This structural and immune characterization provides insights into coronavirus spike stability determinants and explores the immune landscape of viral spike proteins. |
リンク | Structure / PubMed:33378641 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.5 - 28.0 Å |
構造データ | EMDB-21391, PDB-6vv5: EMDB-21392: EMDB-21393: EMDB-21394: EMDB-21395: EMDB-21396: EMDB-21397: EMDB-21398: EMDB-21399: EMDB-21400: EMDB-21401: EMDB-21402: EMDB-21403: EMDB-21404: |
化合物 | ChemComp-NAG: ChemComp-PAM: |
由来 |
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キーワード | VIRAL PROTEIN / glycoprotein / surface / receptor-binding / membrane fusion |