EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.
ジャーナル・号・ページ	Cell, Vol. 177, Issue 5, Page 1153-1171.e28, Year 2019
掲載日	2019年5月16日
著者	Kimberly M Cirelli / Diane G Carnathan / Bartek Nogal / Jacob T Martin / Oscar L Rodriguez / Amit A Upadhyay / Chiamaka A Enemuo / Etse H Gebru / Yury Choe / Federico Viviano / Catherine Nakao / Matthias G Pauthner / Samantha Reiss / Christopher A Cottrell / Melissa L Smith / Raiza Bastidas / William Gibson / Amber N Wolabaugh / Mariane B Melo / Benjamin Cossette / Venkatesh Kumar / Nirav B Patel / Talar Tokatlian / Sergey Menis / Daniel W Kulp / Dennis R Burton / Ben Murrell / William R Schief / Steven E Bosinger / Andrew B Ward / Corey T Watson / Guido Silvestri / Darrell J Irvine / Shane Crotty /
PubMed 要旨	Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of the ...Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of the immunological hurdles posed, including B cell immunodominance and germinal center (GC) quantity and quality. We found that two independent methods of slow delivery immunization of rhesus monkeys (RMs) resulted in more robust T follicular helper (T) cell responses and GC B cells with improved Env-binding, tracked by longitudinal fine needle aspirates. Improved GCs correlated with the development of >20-fold higher titers of autologous nAbs. Using a new RM genomic immunoglobulin locus reference, we identified differential IgV gene use between immunization modalities. Ab mapping demonstrated targeting of immunodominant non-neutralizing epitopes by conventional bolus-immunized animals, whereas slow delivery-immunized animals targeted a more diverse set of epitopes. Thus, alternative immunization strategies can enhance nAb development by altering GCs and modulating the immunodominance of non-neutralizing epitopes.
リンク	Cell / PubMed:31080066 / PubMed Central
手法	EM (単粒子)
解像度	16.4 - 29.5 Å
構造データ	EMDB-0569: HIV-1 vaccine elicited polyclonal 5N6 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 19.6 Å EMDB-0570: HIV-1 vaccine elicited polyclonal 99-13 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 24.5 Å EMDB-0571: HIV-1 vaccine elicited polyclonal 145-11 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 18.45 Å EMDB-0572: HIV-1 vaccine elicited polyclonal BM57 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 24.6 Å EMDB-0573: HIV-1 vaccine elicited polyclonal BO77 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 18.45 Å EMDB-0574: HIV-1 vaccine elicited polyclonal BO77 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 19.6 Å EMDB-0575: HIV-1 vaccine elicited polyclonal RAa14 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 19.7 Å EMDB-0576: HIV-1 vaccine elicited polyclonal RAv16 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 29.5 Å EMDB-0577: HIV-1 vaccine elicited polyclonal RAv16 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 26.38 Å EMDB-0578: HIV-1 vaccine elicited polyclonal REj15 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 24.6 Å EMDB-0579: HIV-1 vaccine elicited polyclonal REv16 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 16.4 Å EMDB-0580: HIV-1 vaccine elicited polyclonal RHw16 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 18.45 Å EMDB-0581: HIV-1 vaccine elicited polyclonal RMI15 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 22.7 Å EMDB-0582: HIV-1 vaccine elicited polyclonal RWo16 Fab in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 16.4 Å EMDB-9138: HIV-1 vaccine elicited Fab BDA1 in complex with the HIV Env trimer BG505 SOSIPv5.2 手法: EM (単粒子) / 解像度: 21.0 Å EMDB-9175: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate 224-13 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9176: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RCn 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9177: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RFr16 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9178: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate ROw16 手法: EM (単粒子) / 解像度: 24.6 Å EMDB-9179: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RQq16 手法: EM (単粒子) / 解像度: 29.5 Å EMDB-9180: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RRk16 手法: EM (単粒子) / 解像度: 24.5 Å EMDB-9181: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RVh16 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9182: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RTh16 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9183: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RWh16 手法: EM (単粒子) / 解像度: 26.8 Å EMDB-9184: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RWr16 手法: EM (単粒子) / 解像度: 24.5 Å EMDB-9185: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate RYm16 手法: EM (単粒子) / 解像度: 16.4 Å EMDB-9186: Negative Stain EM map of polyclonal serum in complex with BG505 SOSIP.664 from non-human primate ROw16 手法: EM (単粒子) / 解像度: 24.5 Å
由来	Homo sapiens (ヒト) Macaca (マカク属) Human immunodeficiency virus 1 (ヒト免疫不全ウイルス) Macaca mulatta (アカゲザル)