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Title | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 14809-14831, Year 2022 |
Publish date | Jun 29, 2022 (structure data deposition date) |
Authors | Yang, F. / Chen, X. / Song, X. / Ortega, R. / Lin, X. / Deng, W. / Guo, J. / Tu, Z. / Patterson, A.V. / Smaill, J.B. ...Yang, F. / Chen, X. / Song, X. / Ortega, R. / Lin, X. / Deng, W. / Guo, J. / Tu, Z. / Patterson, A.V. / Smaill, J.B. / Chen, Y. / Lu, X. |
External links | J. Med. Chem. / PubMed:36278929 |
Methods | X-ray diffraction |
Resolution | 1.987 - 2.535 Å |
Structure data | PDB-7ybo: PDB-7ybp: PDB-7ybx: PDB-7yc1: PDB-7yc3: |
Chemicals | ChemComp-IH7: ChemComp-SO4: ChemComp-HOH: ChemComp-IIQ: ChemComp-GOL: ChemComp-IIW: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / Kinase / Inhibitor / STRUCTURAL PROTEIN / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / TRANSFERASE-INHIBITOR complex |