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Structure paper

TitleHow IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Journal, issue, pagesStructure, Vol. 28, Issue 7, Page 786-798.e6, Year 2020
Publish dateJul 7, 2020
AuthorsYibin Xu / Nicholas S Kirk / Hariprasad Venugopal / Mai B Margetts / Tristan I Croll / Jarrod J Sandow / Andrew I Webb / Carlie A Delaine / Briony E Forbes / Michael C Lawrence /
PubMed AbstractHuman type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth ...Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like growth factor I. Here, we describe the cryoelectron microscopy structure of insulin-like growth factor II bound to a leucine-zipper-stabilized IGF-1R ectodomain, determined in two conformations to a maximum average resolution of 3.2 Å. The two conformations differ in the relative separation of their respective points of membrane entry, and comparison with the structure of insulin-like growth factor I bound to IGF-1R reveals long-suspected differences in the way in which the critical C domain of the respective growth factors interact with IGF-1R.
External linksStructure / PubMed:32459985 / PubMed Central
MethodsEM (single particle)
Resolution3.21 - 4.26 Å
Structure data

21415

6vwg

EMDB-21415, PDB-6vwg:
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Method: EM (single particle) / Resolution: 3.21 Å

21416

6vwh

EMDB-21416, PDB-6vwh:
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Method: EM (single particle) / Resolution: 4.26 Å

21417

6vwi

EMDB-21417: Head region of the close conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
PDB-6vwi: Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Method: EM (single particle) / Resolution: 3.7 Å

21418

6vwj

EMDB-21418, PDB-6vwj:
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II
Method: EM (single particle) / Resolution: 4.21 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsSIGNALING PROTEIN / Type 1 insulin-like growth factor receptor / Insulin-like growth factor II / ectodomain receptor / tyrosine kinase

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