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-Structure paper
Title | Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 3495-3499, Year 2008 |
Publish date | Nov 19, 2007 (structure data deposition date) |
Authors | Xu, G. / Searle, L.L. / Hughes, T.V. / Beck, A.K. / Connolly, P.J. / Abad, M.C. / Neeper, M.P. / Struble, G.T. / Springer, B.A. / Emanuel, S.L. ...Xu, G. / Searle, L.L. / Hughes, T.V. / Beck, A.K. / Connolly, P.J. / Abad, M.C. / Neeper, M.P. / Struble, G.T. / Springer, B.A. / Emanuel, S.L. / Gruninger, R.H. / Pandey, N. / Adams, M. / Moreno-Mazza, S. / Fuentes-Pesquera, A.R. / Middleton, S.A. / Greenberger, L.M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18508264 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-3bel: |
Chemicals | ChemComp-PO4: ChemComp-POX: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / kinase domain / Alternative splicing / Anti-oncogene / ATP-binding / Cell cycle / Disease mutation / Glycoprotein / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Secreted / Transmembrane / Tyrosine-protein kinase / Ubl conjugation |