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TitleA structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.
Journal, issue, pagesScience, Vol. 343, Issue 6171, Page 656-661, Year 2014
Publish dateFeb 7, 2014
AuthorsRajesh K Grover / Xueyong Zhu / Travis Nieusma / Teresa Jones / Isabel Boreo / Amanda S MacLeod / Adam Mark / Sherry Niessen / Helen J Kim / Leopold Kong / Nacyra Assad-Garcia / Keehwan Kwon / Marta Chesi / Vaughn V Smider / Daniel R Salomon / Diane F Jelinek / Robert A Kyle / Richard B Pyles / John I Glass / Andrew B Ward / Ian A Wilson / Richard A Lerner /
PubMed AbstractWe report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known ...We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the κ and λ light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field.
External linksScience / PubMed:24503852 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.2 - 21.3 Å
Structure data

EMDB-5834:
A Unique Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union
Method: EM (single particle) / Resolution: 21.3 Å

EMDB-5835:
A Unique Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-5836:
A Unique Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union
Method: EM (single particle) / Resolution: 16.8 Å

PDB-4nzr:
Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-HIV antibody PGT135 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-4nzt:
Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-infleunza hemagglutinin antibody CR9114 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.497 Å

PDB-4nzu:
Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

Source
  • mycoplasma genitalium (bacteria)
  • homo sapiens (human)
  • unidentified (others)
KeywordsIMMUNE SYSTEM/PROTEIN BINDING / Leucine-rich repeat / broad antibody-binding / block antibody-antigen union / variable region / IMMUNE SYSTEM-PROTEIN BINDING complex / PROTEIN BINDING/IMMUNE SYSTEM / PROTEIN BINDING-IMMUNE SYSTEM complex / IMMUNE SYSTEM / antibody Fab / multiple myeloma / primary antibody

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