タイトル | Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism |
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ジャーナル・号・ページ | Rsc Chem Biol, Year 2025 |
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掲載日 | 2025年5月28日 (構造データの登録日) |
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著者 | Zhang, N. / Pow, K.C. / Chen, L. / Hao, Q. |
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リンク | Rsc Chem Biol / PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.61 - 2.68 Å |
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構造データ | PDB-9v7w: SIRT2 structure in complex with H3K18myr peptide and native NAD: pre-catalysis state 3 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-9vem: SIRT2 structure in complex with H3K18myr peptide and native NAD: pre-catalysis state 1 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-9vew: SIRT2 structure in complex with H3K18myr peptide and native NAD: pre-catalysis state 2 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-9vg0: SIRT2 structure in complex with H3K18myr peptide 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-9vg3: SIRT2 structure in complex with H3K18myr peptide: pre NAD binding state 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-9vge: SIRT2 demyristoylation intermediate I structure 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-9vgz: SIRT2-F96A structure in complex with H3K18myr peptide and native NAD 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-9vh0: SIRT2-H187A structure in complex with H3K18myr peptide and native NAD 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å |
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化合物 | ChemComp-NAD: NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM
ChemComp-YDD: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5S)-3,4-bis(oxidanyl)-5-tetradecoxy-oxolan-2-yl]methyl hydrogen phosphate
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由来 | homo sapiens (ヒト)
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キーワード | HYDROLASE / Deacylase / Cell Cycle Regulation / Metabolic Regulation / Deacylated / deacetylase |
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