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Structure paper

TitleSubstrate Recognition, Directional Flux, and Allostery in a Synaptic Vesicle Glutamate Transporter
Journal, issue, pagesTo Be Published
Publish dateDec 8, 2021 (structure data deposition date)
AuthorsLi F / Stroud RM
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.0 - 3.3 Å
Structure data

25665

7t3n

EMDB-25665, PDB-7t3n:
R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2)
Method: EM (single particle) / Resolution: 3.0 Å

25666

7t3o

EMDB-25666, PDB-7t3o:
Rat vesicular glutamate transporter 2 (VGLUT2) in low Cl condition
Method: EM (single particle) / Resolution: 3.3 Å

Chemicals

ChemComp-C5B:
(1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID

ChemComp-I7Y:
(2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSPORT PROTEIN / synaptic vesicle / neurotransmitter / glutamate transport

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