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Structure paper

TitleHIF-2alpha-pVHL-elongin B-elongin C complex
Journal, issue, pagesTo Be Published
Publish dateNov 17, 2018 (structure data deposition date)
AuthorsChowdhury, R. / Schofield, C.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.798 - 1.949 Å
Structure data

PDB-6i7q:
Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form
Method: X-RAY DIFFRACTION / Resolution: 1.798 Å

PDB-6i7r:
Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the P43212 form
Method: X-RAY DIFFRACTION / Resolution: 1.949 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
  • bos taurus (domestic cattle)
KeywordsGENE REGULATION / E3 UBIQUITIN LIGASE / von Hippel Lindau / Prolyl hydroxylation / HIF / TUMOR SUPPRESSOR / CANCER / PROTEOSOMAL DEGRADATION / UBIQUITIN

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