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Structure paper

TitleVenom protection by antibody from a snakebite hyperimmune subject
Journal, issue, pagesTo Be Published
Publish dateJun 12, 2022 (structure data deposition date)
AuthorsGlanville, J. / Andrade, J. / Bellin, M. / Kim, S. / Pletnev, S. / Tsao, D. / Verardi, R. / Bedi, R. / Friede, T. / Tully, E. ...Glanville, J. / Andrade, J. / Bellin, M. / Kim, S. / Pletnev, S. / Tsao, D. / Verardi, R. / Bedi, R. / Friede, T. / Tully, E. / Zhang, B. / Bylund, T. / Liu, T. / Kwong, P.D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 - 2.67 Å
Structure data

PDB-8d9y:
Crystal structure of Taipan alpha-neurotoxin in complex with Centi-LNX-D09 antibody
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8d9z:
Crystal structure of Cobra alpha-neurotoxin in complex with Centi-LNX-D09 antibody
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8da0:
Crystal structure of Mamba alpha-neurotoxin in complex with Centi-LNX-D09 antibody
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8da1:
Crystal structure of Krait alpha-neurotoxin in complex with Centi-LNX-D09 antibody
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • oxyuranus scutellatus scutellatus (Australian taipan)
  • naja nivea (cape cobra)
  • dendroaspis polylepis polylepis (black mamba)
  • bungarus multicinctus (many-banded krait)
KeywordsIMMUNE SYSTEM / ANTITOXIN/TOXIN / antivenom / 3-finger toxin / alpha-neurotoxin / long neurotoxin 1 / antibody / ANTITOXIN / ANTITOXIN-TOXIN complex

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