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TitleStructural insights into epitope-paratope interactions of monoclonal antibody targeting CEACAM5-expressing tumors
Journal, issue, pagesRes Sq, Year 2023
Publish dateDec 6, 2022 (structure data deposition date)
AuthorsRak A / Kumar A / Duffi F / Gagnaire M / Rapisarda C / Bertrand T
External linksRes Sq / Search PubMed
MethodsEM (single particle)
Resolution3.11 Å
Structure data

16279

8bw0

EMDB-16279, PDB-8bw0:
Structure of CEACAM5 A3-B3 domain in Complex with Tusamitamab Fab
Method: EM (single particle) / Resolution: 3.11 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • mus sp. (mice)
KeywordsCELL ADHESION / CEACAM5 / Tusamitamab / Cancer / cryo-EM / small molecular weight / Fab / A3-B3 / human membrane protein

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