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Structure paper

TitleStructures of butyrophilin multimers reveal a plier-like mechanism for V gamma 9V delta 2 T cell receptor activation
Journal, issue, pagesImmunity, Year 2025
Publish dateSep 27, 2024 (structure data deposition date)
AuthorsZhang M / Wang Y / Cai N / Qu Y / Ma X / Xue J / Chen X / Zhang X / Xiao J / Zhang Y
External linksImmunity / Search PubMed
MethodsEM (single particle)
Resolution3.0 - 4.51 Å
Structure data

61724

9jq6

EMDB-61724, PDB-9jq6:
Cryo-EM structure of BTN2A1 in complex with antagonist antibody TH002
Method: EM (single particle) / Resolution: 3.34 Å

61732

9jqp

EMDB-61732, PDB-9jqp:
Cryo-EM structure of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 in complex with agonist antibody TH001
Method: EM (single particle) / Resolution: 3.34 Å

EMDB-61733: Extracellular region of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 complex (EMReady)
Method: EM (single particle) / Resolution: 4.17 Å

EMDB-61734: TM/JM/B30.2 regions of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 complex (EMReady)
Method: EM (single particle) / Resolution: 3.58 Å

EMDB-61735: Raw consensus map of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 complex
Method: EM (single particle) / Resolution: 3.74 Å

61736

9jqq

EMDB-61736, PDB-9jqq:
Cryo-EM structure of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 complex
Method: EM (single particle) / Resolution: 3.26 Å

EMDB-61737: Extracellular region of the Vgamma9Vdelta2 TCR-engaged BTN3A1-BTN3A2-BTN2A1 complex (EMReady)
Method: EM (single particle) / Resolution: 3.21 Å

EMDB-61738: TM/JM/B30.2 regions of the Vgamma9Vdelta2 TCR-engaged BTN3A1-BTN3A2-BTN2A1 complex (EMReady)
Method: EM (single particle) / Resolution: 4.51 Å

EMDB-61739: Raw consensus map of the Vgamma9Vdelta2 TCR-engaged BTN3A1-BTN3A2-BTN2A1 complex
Method: EM (single particle) / Resolution: 3.22 Å

61740

9jqr

EMDB-61740, PDB-9jqr:
Cryo-EM structure of the Vgamma9Vdelta2 TCR-engaged BTN3A1-BTN3A2-BTN2A1 complex
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-H6P:
(2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / receptor / butyrophilin / antagonist / antibody / agonist / phosphoantigen

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