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TitleEnhanced binding of Sialyl Lewis X to hemagglutinin contributes to H5N8 mammalian pathogenicity and infectivity
Journal, issue, pagesTo Be Published
Publish dateNov 9, 2023 (structure data deposition date)
AuthorsJin X / Han P / Zhang C / Maio AD / Shi Y / Qi J / Bi Y / Liu Y / Song H / Gao GF
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution2.48 - 3.19 Å
Structure data

38008

8x2f

EMDB-38008, PDB-8x2f:
Cryo-EM structure of H5 hemagglutinin from human-infecting H5N8 influenza virus in complex with Sialyl-Lewis X
Method: EM (single particle) / Resolution: 2.62 Å

PDB-8x26:
Crystal structure of H5 hemagglutinin from human-infecting H5N8 influenza virus in complex with LSTa
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

PDB-8x27:
Crystal structure of H5 hemagglutinin from human-infecting H5N8 influenza virus in complex with LSTc
Method: X-RAY DIFFRACTION / Resolution: 3.04 Å

PDB-8x28:
Crystal structure of H5 hemagglutinin from human-infecting H5N8 influenza virus
Method: X-RAY DIFFRACTION / Resolution: 3.19 Å

PDB-8x29:
Crystal structure of H5 hemagglutinin from swan-infecting H5N8 influenza virus in complex with LSTa
Method: X-RAY DIFFRACTION / Resolution: 2.613 Å

PDB-8x2c:
Crystal structure of H5 hemagglutinin from swan-infecting H5N8 influenza virus
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-8x2d:
Crystal structure of H5 hemagglutinin from swan-infecting H5N8 influenza virus complexed with avian receptor analog LSTc
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GAL:
beta-D-galactopyranose

ChemComp-SIA:
N-acetyl-alpha-neuraminic acid

ChemComp-HOH:
WATER

Source
  • influenza a virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / VIRAL PROTEIN

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