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Structure paper

TitleInhibition of Origin Recognition Complex by Cyclin Dependent Kinase Reveals Alternate Mechanism of MCM Loading
Journal, issue, pagesTo Be Published
Publish dateDec 18, 2023 (structure data deposition date)
AuthorsMiller TCR / Lim CT / Diffley JFX / Costa A
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.79 - 3.41 Å
Structure data

19186

8rif

EMDB-19186, PDB-8rif:
Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
Method: EM (single particle) / Resolution: 2.79 Å

19187

8rig

EMDB-19187, PDB-8rig:
Cryo-EM structure of an MCM helicase single hexamer loaded onto dsDNA.
Method: EM (single particle) / Resolution: 3.41 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae s288c (yeast)
KeywordsREPLICATION / MCM helicase / DNA replication

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