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Structure paper

TitleTargeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors
Journal, issue, pagesTo be Published
Publish dateOct 3, 2010 (structure data deposition date)
AuthorsIgonet, S. / Vaney, M.C. / Bartonova, V. / Helma, J. / Rothbauer, U. / Leonhardt, H. / Stura, E. / Krausslich, H.-G. / Rey, F.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.32 - 1.89 Å
Structure data

PDB-2xt1:
Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 231) in complex with a camelid VHH.
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-2xv6:
Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH.
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-2xxc:
Crystal structure of a camelid VHH raised against the HIV-1 capsid protein C-terminal domain.
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-2xxm:
Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide.
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

Source
  • human immunodeficiency virus 1
  • vicugna pacos (alpaca)
  • human immunodeficiency virus
  • synthetic construct (others)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / IMMUNE SYSTEM / IMMUNE SYSTEM/PEPTIDE / IMMUNE SYSTEM-PEPTIDE COMPLEX / CAPSID INHIBITOR / PROTEIN BINDING / PROTEIN INTERFACE / VIRUS ASSEMBLY

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