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Structure paper

TitleEffective tubulin degradation by rationally designed Proteolysis Targeting Chimeras
Journal, issue, pagesTo Be Published
Publish dateOct 15, 2024 (structure data deposition date)
AuthorsMaiocchi, A. / Abel, A.-C. / Basellini, M. / Perez Pena, H. / Boiarska, Z. / Ferrandi, E. / Kozicka, Z. / Fasano, V. / Pieraccini, S. / Cappelletti, G. ...Maiocchi, A. / Abel, A.-C. / Basellini, M. / Perez Pena, H. / Boiarska, Z. / Ferrandi, E. / Kozicka, Z. / Fasano, V. / Pieraccini, S. / Cappelletti, G. / Steinmetz, M.O. / Prota, A.E. / Passarella, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 - 2.5 Å
Structure data

PDB-9h30:
VHL:ElonginC:ElonginB-PROTAC4 complex
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-9h31:
T2R-TTL-PROTAC4 complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-9h32:
T2R-TTL-PROTAC3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-9h33:
T2R-TTL-PROTAC2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9h34:
T2R-TTL-PROTAC1 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

PDB-1ise:
Crystal structure of a mutant of ribosome recycling factor from Escherichia coli, Arg132Gly

ChemComp-HOH:
WATER

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM


PDB Unreleased entry

PDB-1isd: Unknown entry

ChemComp-GOL:
GLYCEROL

PDB-1isc:
STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS

PDB-1isb:
STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsLIGASE / PROTEIN COMPLEX / UBIQUITIN LIGASE / PROTAC / TUBULIN DEGRADATION / CELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE

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