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Structure paper

TitleInhibitor bound Vo subcomplex from human V-ATPase
Journal, issue, pagesTo Be Published
Publish dateAug 29, 2024 (structure data deposition date)
AuthorsOot RA / Park JB / Roh S-H / Wilkens S
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.0 - 3.34 Å
Structure data

EMDB-46795: Human V-ATPase Vo subcomplex bound to inhibitor and nanobody
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-46796: Human V-ATPase Vo subcomplex bound to inhibitor and nanobody
Method: EM (single particle) / Resolution: 3.34 Å

46798

9det

EMDB-46798, PDB-9det:
Human V-ATPase Vo subcomplex (containing subunit isoform a4) bound to nanobody and inhibitor
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CLR:
CHOLESTEROL

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

PDB-1a4q:
INFLUENZA VIRUS B/BEIJING/1/87 NEURAMINIDASE COMPLEXED WITH DIHYDROPYRAN-PHENETHYL-PROPYL-CARBOXAMIDE

ChemComp-WJP:
methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / V-ATPase / lipid nanodisc / Vo subcomplex / inhibitor

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