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| Title | Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design |
|---|---|
| Journal, issue, pages | Biorxiv, Year 2025 |
| Publish date | Sep 30, 2025 (structure data deposition date) |
Authors | Verhoef CJA / Crowe C / Nakasone MA / DeLaCuadra-Baste A / Harzing T / Span NAS / Sathe G / Iso K / Ottmann C / Brunsveld L ...Verhoef CJA / Crowe C / Nakasone MA / DeLaCuadra-Baste A / Harzing T / Span NAS / Sathe G / Iso K / Ottmann C / Brunsveld L / Ciulli A / Cossar PJ |
External links | Biorxiv / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 4.3 - 6.5 Å |
| Structure data | EMDB-55233, PDB-9sv3: ![]() EMDB-55234: EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 1 ![]() EMDB-55235: EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 2.1 ![]() EMDB-55236: EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 2.2 ![]() EMDB-55237: EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 3 |
| Chemicals | ![]() PDB-1jqt: |
| Source |
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Keywords | LIGASE / E3 ligase / von Hippel-Lindau / VHL / 14-3-3 / estrogen receptor alpha / PROTAC / proteolysis targeting chimera / degrader |
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homo sapiens (human)
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