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TitleStructures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
Journal, issue, pagesJ. Mol. Biol., Vol. 282, Page 1061-1081, Year 1998
Publish dateJun 18, 1998 (structure data deposition date)
AuthorsJing, H. / Babu, Y.S. / Moore, D. / Kilpatrick, J.M. / Liu, X.Y. / Volanakis, J.E. / Narayana, S.V.
External linksJ. Mol. Biol. / PubMed:9753554
MethodsX-ray diffraction
Resolution1.5 - 2.3 Å
Structure data

PDB-1bio:
HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-1hfd:
HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SOA:
ISATOIC ANHYDRIDE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSERINE PROTEASE / HYDROLASE / COMPLEMENT / FACTOR D / CATALYTIC TRIAD / SELF-REGULATION

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