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Structure paper

TitleCrystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
Journal, issue, pagesEMBO J., Vol. 17, Page 3219-3232, Year 1998
Publish dateMay 12, 1998 (structure data deposition date)
AuthorsSchumacher, M.A. / Carter, D. / Scott, D.M. / Roos, D.S. / Ullman, B. / Brennan, R.G.
External linksEMBO J. / PubMed:9628859
MethodsX-ray diffraction
Resolution1.93 - 2.5 Å
Structure data

PDB-1bd3:
STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-1bd4:
UPRT-URACIL COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1upf:
STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1upu:
STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V, BOUND TO PRODUCT URIDINE-1-MONOPHOSPHATE (UMP)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-URA:
URACIL

ChemComp-SO4:
SULFATE ION

ChemComp-URF:
5-FLUOROURACIL / medication, chemotherapy*YM

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

Source
  • toxoplasma gondii (eukaryote)
KeywordsTRANSFERASE / GLYCOSYLTRANSFERASE / UPRTASE / UPRT / URACIL / COMPLEX / PHOSPHORIBOSYLTRANSFERASE

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