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Structure paper

TitleThe mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.5G9 complex.
Journal, issue, pagesJ. Mol. Biol., Vol. 275, Page 873-894, Year 1998
Publish dateApr 10, 1997 (structure data deposition date)
AuthorsHuang, M. / Syed, R. / Stura, E.A. / Stone, M.J. / Stefanko, R.S. / Ruf, W. / Edgington, T.S. / Wilson, I.A.
External linksJ. Mol. Biol. / PubMed:9480775
MethodsX-ray diffraction
Resolution2.4 - 3 Å
Structure data

PDB-1ahw:
A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-1fgn:
MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1tfh:
EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsCOMPLEX (IMMUNOGLOBULIN/TISSUE FACTOR) / BLOOD COAGULATION / TISSUE FACTOR / FAB / COMPLEX / ANTIBODY / COMPLEX (IMMUNOGLOBULIN-TISSUE FACTOR) / COMPLEX (IMMUNOGLOBULIN-TISSUE FACTOR) complex / IMMUNOGLOBULIN / ANTI-TF / MONOCLONAL / MURINE / COAGULATION FACTOR / GLYCOPROTEIN

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