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Structure paper

TitleVL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.
Journal, issue, pagesProteins, Vol. 29, Page 161-171, Year 1997
Publish dateFeb 19, 1997 (structure data deposition date)
AuthorsBanfield, M.J. / King, D.J. / Mountain, A. / Brady, R.L.
External linksProteins / PubMed:9329081
MethodsX-ray diffraction
Resolution2.1 - 3 Å
Structure data

PDB-1ad0:
FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1ad9:
IGG-FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1ae6:
IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-1clo:
ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNOGLOBULIN / FAB FRAGMENT / HUMANISATION / FAB-FRAGMENT

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