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Structure paper

TitleThe isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Journal, issue, pagesProtein Sci., Vol. 3, Page 2254-2271, Year 1994
Publish dateJun 27, 1994 (structure data deposition date)
AuthorsVijayalakshmi, J. / Padmanabhan, K.P. / Mann, K.G. / Tulinsky, A.
External linksPubMed:7756983
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-1hag:
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1hah:
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1hai:
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

Source
  • homo sapiens (human)
  • hirudo medicinalis (medicinal leech)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / COMPLEX(SERINE PROTEINASE-INHIBITOR) / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / COMPLEX(SERINE PROTEINASE/INHIBITOR) / COMPLEX(SERINE PROTEINASE-INHIBITOR) complex / SERINE PROTEINASE

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