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TitleSelective CDK2 Degradation via Noncanonical Recruitment.
Journal, issue, pagesJ. Med. Chem., Year 2026
Publish dateFeb 16, 2026 (structure data deposition date)
AuthorsPei, Y. / Lin, W. / Li, X. / Meng, Y. / Yin, Y. / Pan, B. / Zhou, L. / Cao, L. / Cang, Y. / Jiang, Y. ...Pei, Y. / Lin, W. / Li, X. / Meng, Y. / Yin, Y. / Pan, B. / Zhou, L. / Cao, L. / Cang, Y. / Jiang, Y. / Lu, W. / Meng, Z.
External linksJ. Med. Chem. / PubMed:42334090
MethodsEM (single particle)
Resolution2.85 Å
Structure data

PDB-23sr:
Cryo-EM structure of CDK2 in complex with CRBN/DDB1 and B11
Method: ELECTRON MICROSCOPY / Resolution: 2.85 Å

Chemicals

PDB-1e59:
E.coli cofactor-dependent phosphoglycerate mutase complexed with vanadate

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsCELL CYCLE / Cyclin-Dependent Kinase 2 / Cereblon / Molecular glue / Complex

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