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TitleMolecular basis of polyadenylated RNA fate determination in the nucleus.
Journal, issue, pagesNature, Year 2026
Publish dateFeb 25, 2026 (structure data deposition date)
AuthorsBugai, A. / Hohmann, U. / Lorenzo, A. / Graf, M. / Fin, L. / Rouviere, J.O. / Tirian, L. / Dou, Y. / Le Rest, M. / Polak, P. ...Bugai, A. / Hohmann, U. / Lorenzo, A. / Graf, M. / Fin, L. / Rouviere, J.O. / Tirian, L. / Dou, Y. / Le Rest, M. / Polak, P. / Johnsen, D. / Jakobsen, L. / Andersen, J.S. / Brennecke, J. / Plaschka, C. / Jensen, T.H.
External linksNature / PubMed:42310446
MethodsEM (single particle)
Resolution2.62 - 6.2 Å
Structure data

PDB-28wy:
Cryo-EM structure of the human SAC3D1-PCID2-SEM1 complex
Method: ELECTRON MICROSCOPY / Resolution: 3.6 Å

PDB-28wz:
Cryo-EM structure of the human LENG8-PCID2-SEM1 complex
Method: ELECTRON MICROSCOPY / Resolution: 3.5 Å

PDB-28xa:
Cryo-EM structure of the human UAP56 NTD - LENG8-PCID2-SEM1 complex
Method: ELECTRON MICROSCOPY / Resolution: 4.86 Å

PDB-28xb:
Cryo-EM structure of the human UAP56-RNA - LENG8-PCID2-SEM1 complex
Method: ELECTRON MICROSCOPY / Resolution: 6.2 Å

PDB-9rv1:
Cryo-EM structure of the human UAP56-RNA - SAC3D1-PCID2-SEM1 complex
Method: ELECTRON MICROSCOPY / Resolution: 2.62 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • homo sapiens (human)
KeywordsGENE REGULATION / mRNA export

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