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Structure paper

TitleUnderstanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis.
Journal, issue, pagesActa Crystallogr D Struct Biol, Year 2025
Publish dateOct 5, 2021 (structure data deposition date)
AuthorsSalinas-Garcia, M.C. / Plaza-Garrido, M. / Martinez, J.C. / Camara-Artigas, A.
External linksActa Crystallogr D Struct Biol / PubMed:40862305
MethodsX-ray diffraction
Resolution1.05 - 2 Å
Structure data

PDB-7pvq:
Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P21221
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-7pvs:
Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in presence of PEG 200
Method: X-RAY DIFFRACTION / Resolution: 1.05 Å

PDB-7pvv:
Crystal structure of the Abl SH3 domain G92N-Y93N-N94T-H95E mutant
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-7pvw:
Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H mutant
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-7pvy:
Crystal structure of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-7pvz:
Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7pw0:
Crystal structure of the c-Src SH3 domain N112G-N113Y-T114N-E115H mutant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-7pw2:
Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E mutant
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • gallus gallus (chicken)
KeywordsPROTEIN BINDING / beta barrel / SH3 domain

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