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TitleCharacterization of the glycoproteins of novel fish influenza B-like viruses.
Journal, issue, pagesbioRxiv, Year 2025
Publish dateMay 8, 2025
AuthorsGagandeep Singh / Jiachen Huang / Disha Bhavsar / Kirill Vasilev / James A Ferguson / Geert-Jan Boons / Viviana Simon / Robert P de Vries / Julianna Han / Andrew Ward / Florian Krammer /
PubMed AbstractNovel influenza-like virus sequences previously identified in fish and amphibians were found to cluster as a sister clade of influenza B viruses, but have thus far remained uncharacterized. We ...Novel influenza-like virus sequences previously identified in fish and amphibians were found to cluster as a sister clade of influenza B viruses, but have thus far remained uncharacterized. We demonstrate that salamander influenza-like virus (SILV) HA is functionally divergent from influenza B virus HA and does not bind to α 2,3- and α2,6-linked sialic acids. However, the HAs of Siamese algae-eater influenza-like virus (SAEILV) and chum salmon influenza-like virus (CSILV) bind to α2,3 linked sialic acid. Furthermore, SAEILV HA binds to sialyated Lewis X, is activated by human airway enzymes and is fusogenic at a wide range of pH conditions. SAEILV NA has a highly conserved active site and a similar structure to other known NAs. We also determined the cryo-electron microscopy structure of the HA of a previously described virus from the same sister clade, the Wuhan spiny eel influenza virus (WSEIV). Importantly, no cross-reactive antibodies against these HAs or NAs were found in the human serum, suggesting that humans are immunologically naïve to these viruses.
External linksbioRxiv / PubMed:40654808 / PubMed Central
MethodsEM (single particle)
Resolution2.67 - 25.0 Å
Structure data

70148

9o5u

EMDB-70148, PDB-9o5u:
CryoEM structure of Siamese algae-eater influenza-like virus (SAEILV) NA
Method: EM (single particle) / Resolution: 2.75 Å

70149

9o5w

EMDB-70149, PDB-9o5w:
CryoEM structure of Wuhan spiny eel influenza virus (WSEIV) HA
Method: EM (single particle) / Resolution: 2.67 Å

EMDB-70150: Siamese algae-eater influenza-like virus (SAEILV) HA
Method: EM (single particle) / Resolution: 25.0 Å

EMDB-70151: Salamander influenza-like virus (SILV) HA
Method: EM (single particle) / Resolution: 25.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • siamese algae-eater influenza-like virus
  • wuhan spiny eel influenza virus
  • Salamander influenza-like virus
KeywordsHYDROLASE / Siamese algae-eater influenza-like virus / SAEILV / Flu neuraminidase / VIRUS / VIRAL PROTEIN / Wuhan spiny eel influenza virus / WSEIV / Flu Hemagglutinin / HA

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