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TitleNatural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.
Journal, issue, pagesPlos Pathog., Vol. 21, Page e1013057-e1013057, Year 2025
Publish dateMar 6, 2025 (structure data deposition date)
AuthorsKetprasit, N. / Tai, C.W. / Sharma, V.K. / Manickam, Y. / Khandokar, Y. / Ye, X. / Dogovski, C. / Hilko, D.H. / Morton, C.J. / Braun, A.C. ...Ketprasit, N. / Tai, C.W. / Sharma, V.K. / Manickam, Y. / Khandokar, Y. / Ye, X. / Dogovski, C. / Hilko, D.H. / Morton, C.J. / Braun, A.C. / Leeming, M.G. / Siddharam, B. / Shami, G.J. / Pradeepkumar, P.I. / Panjikar, S. / Poulsen, S.A. / Griffin, M.D.W. / Sharma, A. / Tilley, L. / Xie, S.C.
External linksPlos Pathog. / PubMed:40627786
MethodsX-ray diffraction
Resolution1.839 - 2.36 Å
Structure data

PDB-9m5m:
Crystal structure of Plasmodium vivax aspartyl-tRNA synthetase (PvDRS)
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-9m5n:
Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl-adenylate (Asp-AMP) Complex.
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

PDB-9m5o:
Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl sulfamoyl adenosine (Asp-AMS) Complex
Method: X-RAY DIFFRACTION / Resolution: 1.839 Å

PDB-9npj:
Structural studies of reaction hijacking inhibition of a malaria parasite aspartyl-tRNA synthetase.
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-AMO:
ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-DSZ:
5'-O-(L-alpha-aspartylsulfamoyl)adenosine

ChemComp-MG:
Unknown entry

PDB-1b0l:
RECOMBINANT HUMAN DIFERRIC LACTOFERRIN

Source
  • plasmodium vivax (malaria parasite P. vivax)
KeywordsLIGASE / AMINOACYLATION / AMINOACYL-TRNA SYNTHETASE / MALARIA / INHIBITOR / ATP-BINDING / L-ASP / TRNA-BINDING / t-RNA synthetase

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