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TitleStructural basis of Fanconi anemia pathway activation by FANCM.
Journal, issue, pagesEmbo J., Vol. 44, Page 4013-4036, Year 2025
Publish dateDec 3, 2024 (structure data deposition date)
AuthorsBythell-Douglas, R. / van Twest, S. / Abbouche, L. / Dunn, E. / Coulthard, R.J. / Briggs, D.C. / Murphy, V. / Zhang, X. / Tan, W. / Henrikus, S.S. ...Bythell-Douglas, R. / van Twest, S. / Abbouche, L. / Dunn, E. / Coulthard, R.J. / Briggs, D.C. / Murphy, V. / Zhang, X. / Tan, W. / Henrikus, S.S. / Qian, D. / Wu, Y. / Wolf, J. / Rigoreau, L. / Shakeel, S. / Chapman, K.L. / McDonald, N.Q. / Deans, A.J.
External linksEmbo J. / PubMed:40447800
MethodsX-ray diffraction
Resolution2.2 - 2.401 Å
Structure data

PDB-9el5:
FANCM translocase domain bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-9hjo:
FANCM-FAAP24-dsDNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.401 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsNUCLEAR PROTEIN / Translocase / DNA-damage repair / ATPase / DNA-binding / DNA BINDING PROTEIN / Fanconia Anemia / DNA Interstrand Crosslink repair / Nucleic acid binding / Helix-hairpin-Helix

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