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Structure paper

TitleCytotoxicity and Binding to DNA, Lysozyme, Ribonuclease A, and Human Serum Albumin of the Diiodido Analog of Picoplatin.
Journal, issue, pagesInorg. Chem., Vol. 64, Page 8895-8905, Year 2025
Publish dateDec 5, 2024 (structure data deposition date)
AuthorsFerraro, G. / Pracharova, J. / Gotte, G. / Massai, L. / Berecka, M. / Starha, P. / Messori, L. / Merlino, A.
External linksInorg. Chem. / PubMed:40312957
MethodsX-ray diffraction
Resolution1.48 - 3.9 Å
Structure data

PDB-9hlk:
X-ray structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with lysozyme (structure A)
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-9hmk:
X-ray structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with lysozyme (structure B)
Method: X-RAY DIFFRACTION / Resolution: 1.48 Å

PDB-9hmq:
X-structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with lysozyme (structure C)
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-9hn6:
X-ray structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with ribonuclease A
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

PDB-9hnb:
X-ray structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with human serum albumin
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

Chemicals

ChemComp-NH3:
AMMONIA

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-PT:
Unknown entry

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
  • homo sapiens (human)
KeywordsHYDROLASE / metallodrug / picoplatin / analogue / diiodido / protein-metal interaction / diiodido analogue / lysozyme / diiodide analogue / interaction / platin / ribonuclease / albumin

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