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TitleDiscovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 2981-3003, Year 2025
Publish dateJul 16, 2024 (structure data deposition date)
AuthorsDutheuil, G. / Oukoloff, K. / Korac, J. / Lenoir, F. / El Bousmaqui, M. / Probst, N. / Lapin, A. / Nakhabina, G. / Sorlet, C. / Parmentier, N. ...Dutheuil, G. / Oukoloff, K. / Korac, J. / Lenoir, F. / El Bousmaqui, M. / Probst, N. / Lapin, A. / Nakhabina, G. / Sorlet, C. / Parmentier, N. / Karila, D. / Ghavtadze, N. / Casault, P. / Claridge, S. / Sapmaz, S. / Slater, M.J. / Fraser, G.L.
External linksJ. Med. Chem. / PubMed:39883878
MethodsX-ray diffraction
Resolution1.85 - 2 Å
Structure data

PDB-9g4s:
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 56
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-9g4u:
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 31
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9g4w:
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 59
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

PDB-1iii:
CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE

ChemComp-CA:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

PDB-1iik:
CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT CRYO TEMPERATURE

PDB-1iim:
thymidylyltransferase complexed with TTP

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / METTL3 METTL14 inhibitor Epics

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