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TitleSecond-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E Activity in Cancer.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 16, Page 96-100, Year 2025
Publish dateSep 19, 2024 (structure data deposition date)
AuthorsCardenas, E.L. / O'Rourke, R.L. / Menon, A. / Vega-Hernandez, G. / Meagher, J. / Stuckey, J. / Garner, A.L.
External linksAcs Med. Chem. Lett. / PubMed:39811141
MethodsX-ray diffraction
Resolution2.091 Å
Structure data

PDB-9don:
Crystal structure of eIF4e in complex with Compound 5-PA
Method: X-RAY DIFFRACTION / Resolution: 2.091 Å

Chemicals

ChemComp-M7G:
7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE

PDB-1a8p:
FERREDOXIN REDUCTASE FROM AZOTOBACTER VINELANDII

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSLATION / EIF4E / TRANSLATION INITIATION INHIBITOR

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