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-Structure paper
| Title | Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an In Silico Enabled Drug Discovery Platform. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 67, Page 21811-21840, Year 2024 |
| Publish date | Aug 12, 2024 (structure data deposition date) |
 Authors | Igawa, H. / Konst, Z.A. / Therrien, E. / Shelley, M. / Koldso, H. / Bos, P.H. / Negri, A. / Verras, A. / Guo, J. / Dahlgren, M.K. ...Igawa, H. / Konst, Z.A. / Therrien, E. / Shelley, M. / Koldso, H. / Bos, P.H. / Negri, A. / Verras, A. / Guo, J. / Dahlgren, M.K. / Levinson, A. / Parr, B.T. / Kurhade, S.E. / Latthe, P. / Shetty, R. / Santhanakrishnan, S. / Amberg-Johnson, K. / Futran, A.S. / Atsriku, C. / Pelletier, R.D. / Liu, Z. / Bell, J.A. / Bhat, S. / Svensson, M. / Gerasyuto, A.I. |
 External links | J. Med. Chem. / PubMed:39666597 |
| Methods | X-ray diffraction |
| Resolution | 2.32 - 2.53 Å |
| Structure data |  PDB-9d3v:  PDB-9d3w: |
| Chemicals |  PDB-1a5v:  ChemComp-CL:  ChemComp-HOH:  PDB-1a5l: |
| Source |
|
 Keywords | TRANSFERASE/INHIBITOR / protein kinase / inhibitor / kinase domain / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)