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| Title | Discovery of (2 R ,4 R )-4-(( S )-2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer. |
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| Journal, issue, pages | J. Med. Chem., Vol. 67, Page 20827-20841, Year 2024 |
| Publish date | Dec 12, 2023 (structure data deposition date) |
 Authors | Mlynarski, S.N. / Aquila, B.M. / Cantin, S. / Cook, S. / Doshi, A. / Finlay, M.R.V. / Gangl, E.T. / Grebe, T. / Gu, C. / Kawatkar, S.P. ...Mlynarski, S.N. / Aquila, B.M. / Cantin, S. / Cook, S. / Doshi, A. / Finlay, M.R.V. / Gangl, E.T. / Grebe, T. / Gu, C. / Kawatkar, S.P. / Petersen, J. / Pop-Damkov, P. / Schuller, A.G. / Shao, W. / Shields, J.D. / Simpson, I. / Tavakoli, S. / Tentarelli, S. / Throner, S. / Wang, H. / Wang, J. / Wu, D. / Ye, Q. |
 External links | J. Med. Chem. / PubMed:39572889 |
| Methods | X-ray diffraction |
| Resolution | 1.62 - 1.9 Å |
| Structure data |  PDB-8rfa:  PDB-8rg6:  PDB-8rgf:  PDB-8rgu: |
| Chemicals |  ChemComp-MN:  PDB-1hz9:  ChemComp-HOH:  PDB-1h0b:  PDB-1h0a:  ChemComp-DMS:  ChemComp-PRO: |
| Source |
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 Keywords | HYDROLASE / Arginase / inhibitor / complex |
homo sapiens (human)