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TitleStructural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.
Journal, issue, pagesLife Sci Alliance, Vol. 8, Year 2025
Publish dateApr 26, 2024 (structure data deposition date)
AuthorsNel, L. / Thaysen, K. / Jamecna, D. / Olesen, E. / Szomek, M. / Langer, J. / Frain, K.M. / Hoglinger, D. / Wustner, D. / Pedersen, B.P.
External linksLife Sci Alliance / PubMed:39455279
MethodsX-ray diffraction
Resolution2.44 - 2.64 Å
Structure data

PDB-9f40:
Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-9f41:
Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with cholesterol bound
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

Chemicals

ChemComp-ERG:
ERGOSTEROL

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CCN:
ACETONITRILE

ChemComp-HOH:
WATER

ChemComp-CLR:
CHOLESTEROL

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsMEMBRANE PROTEIN / ergosterol / vacuole / NCR1 / Niemann-Pick type C protein / cholesterol

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