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TitleIdentification of FDA-approved drugs that induce heart regeneration in mammals.
Journal, issue, pagesNat Cardiovasc Res, Vol. 3, Page 372-388, Year 2024
Publish dateJan 27, 2024 (structure data deposition date)
AuthorsAhmed, M.S. / Nguyen, N.U.N. / Nakada, Y. / Hsu, C.C. / Farag, A. / Lam, N.T. / Wang, P. / Thet, S. / Menendez-Montes, I. / Elhelaly, W.M. ...Ahmed, M.S. / Nguyen, N.U.N. / Nakada, Y. / Hsu, C.C. / Farag, A. / Lam, N.T. / Wang, P. / Thet, S. / Menendez-Montes, I. / Elhelaly, W.M. / Lou, X. / Secco, I. / Tomczyk, M. / Zentilin, L. / Pei, J. / Cui, M. / Dos Santos, M. / Liu, X. / Liu, Y. / Zaha, D. / Walcott, G. / Tomchick, D.R. / Xing, C. / Zhang, C.C. / Grishin, N.V. / Giacca, M. / Zhang, J. / Sadek, H.A.
External linksNat Cardiovasc Res / PubMed:39183959
MethodsX-ray diffraction
Resolution1.91 - 2.45 Å
Structure data

PDB-8vts:
Meis1 homeobox domain bound to paromomycin fragment
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-8vtt:
Meis1 homeobox domain bound to neomycin fragment
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsDNA BINDING PROTEIN / HOMEOBOX DOMAIN / HUMAN HOMEOBOX PROTEIN MEIS2 / DNA-BINDING / TRANSCRIPTION / HOMEOBOX / NUCLEUS / PHOSPHOPROTEIN / HUMAN HOMEOBOX PROTEIN MEIS1

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