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Structure paper

TitleStructural Basis for C2'-methoxy Recognition by DNA Polymerases and Function Improvement.
Journal, issue, pagesJ. Mol. Biol., Vol. 436, Page 168744-168744, Year 2024
Publish dateDec 22, 2023 (structure data deposition date)
AuthorsWen, C. / Wang, G. / Yang, L. / Chen, T. / Liu, H. / Gong, W.
External linksJ. Mol. Biol. / PubMed:39147125
MethodsX-ray diffraction
Resolution1.97 - 2.4 Å
Structure data

PDB-8xjr:
Apo form of DNA polymerase SFM4-3 recognizing C2 methyoxy nucleotide
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-8xk7:
binary complex of DNA polymerase SFM4-3 recognizing C2 methyoxy nucleotide
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8xk9:
ternary complex of DNA polymerase SFM4-3 recognizing C2 methyoxy nucleotide
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-MG:
Unknown entry

PDB-1lwe:
CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE

Source
  • thermus aquaticus (bacteria)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / DNA polymerase

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