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Structure paper

TitleA structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 107612-107612, Year 2024
Publish dateDec 14, 2023 (structure data deposition date)
AuthorsTran, M.T. / Lim, J.J. / Loh, T.J. / Mannering, S.I. / Rossjohn, J. / Reid, H.H.
External linksJ. Biol. Chem. / PubMed:39074636
MethodsX-ray diffraction
Resolution2.4 - 3.5 Å
Structure data

PDB-8vcx:
Human TCR A2.13 in complex with DQ8-InsCpep
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-8vcy:
Human TCR A2.13 in complex with DQ8-InsC8-15NPY
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8vd0:
Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP2
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8vd2:
Human TCR ET650-4 in complex with DQ8-InsC8-15-IAPP1
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8vdd:
Crystal structure of Proinsulin C-peptide bound to HLA-DQ8
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8vdu:
Crystal structure of hybrid insulin peptide (InsC8-15-IAPP74-80) bound to HLA-DQ8
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immune receptor complex / Immune T cell receptor-pMHC II complex / pMHC II complex

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