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Structure paper

TitleBroad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
Journal, issue, pagesiScience, Vol. 27, Issue 7, Page 110354, Year 2024
Publish dateJul 19, 2024
AuthorsCyril Planchais / Ignacio Fernández / Benjamin Chalopin / Timothée Bruel / Pierre Rosenbaum / Maxime Beretta / Jordan D Dimitrov / Laurine Conquet / Flora Donati / Matthieu Prot / Françoise Porrot / Delphine Planas / Isabelle Staropoli / Florence Guivel-Benhassine / Eduard Baquero / Sylvie van der Werf / Ahmed Haouz / Etienne Simon-Lorière / Xavier Montagutelli / Bernard Maillère / Félix A Rey / Pablo Guardado-Calvo / Hervé Nozach / Olivier Schwartz / Hugo Mouquet /
PubMed AbstractAntibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly ...Antibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly neutralizing antibodies cloned from the memory B cells of a single convalescent individual after infection with ancestral SARS-CoV-2. Cv2.3194, a resilient class 1 anti-RBD antibody, remains active against Omicron sub-variants up to BA.2.86. Cv2.3132, a near pan-Sarbecovirus neutralizer, targets the heptad repeat 2 membrane proximal region. When combined, Cv2.3194 and Cv2.3132 form a complementary SARS-CoV-2 neutralizing antibody cocktail exhibiting a local dose-dependent synergy. Thus, remarkably robust neutralizing memory B cell antibodies elicited in response to ancestral SARS-CoV-2 infection can withstand viral evolution and immune escape. The cooperative effect of such antibody combination may confer a certain level of protection against the latest SARS-CoV-2 variants.
External linksiScience / PubMed:39071888 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.87 - 3.2 Å
Structure data

EMDB-18399: SARS-CoV-2 Spike in complex with the neutralizing antibody Cv2.3194
Method: EM (single particle) / Resolution: 3.2 Å

PDB-8qh0:
Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-8qh1:
Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-PRO:
PROLINE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Coronavirus Neutralizing Antibody

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