Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them.
PDB-8opu: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Sulfamethoxazole (Fragment-B-E1) 手法: X-RAY DIFFRACTION / 解像度: 3.04 Å
PDB-8opv: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Resveratrol (Fragment-B-H11) 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å
PDB-8opw: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Caffeine (Fragment-B-51) 手法: X-RAY DIFFRACTION / 解像度: 2.52 Å
PDB-8opx: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Trehalose (Fragment-B-TRE) 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å
PDB-8opy: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-B-DNQ 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å
PDB-8oql: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-1 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å
PDB-8oqm: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-10 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å
PDB-8oqn: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-53 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
PDB-8oqo: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-49 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å
PDB-8oqp: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-76 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å
PDB-8oqq: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-79 手法: X-RAY DIFFRACTION / 解像度: 2.59 Å
PDB-8oqr: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-80 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
PDB-8oqs: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-83 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å
PDB-8oqu: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-92 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å
PDB-8oqv: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-109 手法: X-RAY DIFFRACTION / 解像度: 2.78 Å
PDB-8pf8: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-72 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å