+Search query
-Structure paper
Title | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 67, Page 11254-11272, Year 2024 |
Publish date | Apr 29, 2024 (structure data deposition date) |
![]() | DeRatt, L.G. / Zhang, Z. / Pietsch, C. / Cisar, J.S. / Zhang, X. / Wang, W. / Tanner, A. / Matico, R. / Shaffer, P. / Jacoby, E. ...DeRatt, L.G. / Zhang, Z. / Pietsch, C. / Cisar, J.S. / Zhang, X. / Wang, W. / Tanner, A. / Matico, R. / Shaffer, P. / Jacoby, E. / Kazmi, F. / Shukla, N. / Bush, T.L. / Patrick, A. / Philippar, U. / Attar, R. / Edwards, J.P. / Kuduk, S.D. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.3 - 2.08 Å |
Structure data | ![]() PDB-9bkm: ![]() PDB-9bkn: ![]() PDB-9bko: |
Chemicals | ![]() ChemComp-FMN: ![]() ChemComp-ORO: ![]() ChemComp-GOL: ![]() ChemComp-ACT: ![]() PDB-1aqm: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() PDB-1aqk: ![]() ChemComp-CL: ![]() PDB-1aql: |
Source |
|
![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Dihydroorotate dehydrogenase / DHODH / oxidoreductase / inhibitor / oxidoreductase-inhibitor complex / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |