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TitleStructural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
Journal, issue, pagesScience, Vol. 384, Issue 6703, Page 1453-1460, Year 2024
Publish dateJun 28, 2024
AuthorsYidong Wang / Liang Qiu / Bing Wang / Zeyuan Guan / Zhi Dong / Jie Zhang / Song Cao / Lulu Yang / Bo Wang / Zhou Gong / Liwei Zhang / Weihua Ma / Zhu Liu / Delin Zhang / Guirong Wang / Ping Yin /
PubMed AbstractInsects detect and discriminate a diverse array of chemicals using odorant receptors (ORs), which are ligand-gated ion channels comprising a divergent odorant-sensing OR and a conserved odorant ...Insects detect and discriminate a diverse array of chemicals using odorant receptors (ORs), which are ligand-gated ion channels comprising a divergent odorant-sensing OR and a conserved odorant receptor co-receptor (Orco). In this work, we report structures of the OR5-Orco heterocomplex from the pea aphid alone and bound to its known activating ligand, geranyl acetate. In these structures, three Orco subunits serve as scaffold components that cannot bind the ligand and remain relatively unchanged. Upon ligand binding, the pore-forming helix S7b of OR5 shifts outward from the central pore axis, causing an asymmetrical pore opening for ion influx. Our study provides insights into odorant recognition and channel gating of the OR-Orco heterocomplex and offers structural resources to support development of innovative insecticides and repellents for pest control.
External linksScience / PubMed:38870272
MethodsEM (single particle)
Resolution3.0 - 3.5 Å
Structure data

39858

8z9a

EMDB-39858, PDB-8z9a:
Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate
Method: EM (single particle) / Resolution: 3.0 Å

39873

8z9z

EMDB-39873, PDB-8z9z:
Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum
Method: EM (single particle) / Resolution: 3.5 Å

Chemicals

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM


ChemComp, No image

ChemComp-SOU:
Unknown entry

Source
  • acyrthosiphon pisum (pea aphid)
KeywordsMEMBRANE PROTEIN

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