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Structure paper

TitleA hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2309211121-e2309211121, Year 2024
Publish dateOct 11, 2022 (structure data deposition date)
AuthorsSzodorai, E. / Hevesi, Z. / Wagner, L. / Hokfelt, T.G.M. / Harkany, T. / Schnell, R.
External linksProc. Natl. Acad. Sci. USA / PubMed:38593081
MethodsX-ray diffraction
Resolution2.3 - 2.65 Å
Structure data

PDB-8ban:
Secretagogin (mouse) in complex with its target peptide from SNAP-25
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-8bav:
Secretagogin (human) in complex with its target peptide from SNAP-25
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8bbj:
Secretagogin (mouse) in complex with its target peptide from Syntaxin-4
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-144:
TRIS-HYDROXYMETHYL-METHYL-AMMONIUM

ChemComp-CAC:
CACODYLATE ION

Source
  • aequorea victoria (jellyfish)
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsPEPTIDE BINDING PROTEIN / Calcium-dependent / protein complex / Calcium dependent

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