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Structure paper

TitleDevelopment and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Journal, issue, pagesNat Commun, Vol. 15, Page 2743-2743, Year 2024
Publish dateJan 25, 2023 (structure data deposition date)
AuthorsNayak, D. / Lv, D. / Yuan, Y. / Zhang, P. / Hu, W. / Nayak, A. / Ruben, E.A. / Lv, Z. / Sung, P. / Hromas, R. ...Nayak, D. / Lv, D. / Yuan, Y. / Zhang, P. / Hu, W. / Nayak, A. / Ruben, E.A. / Lv, Z. / Sung, P. / Hromas, R. / Zheng, G. / Zhou, D. / Olsen, S.K.
External linksNat Commun / PubMed:38548768
MethodsX-ray diffraction
Resolution2.56 - 2.98 Å
Structure data

PDB-8fy0:
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

PDB-8fy1:
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2)
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

PDB-8fy2:
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

Chemicals

ChemComp-CAD:
CACODYLIC ACID

ChemComp-GOL:
GLYCEROL


ChemComp, No image

ChemComp-YF8:
Unknown entry


ChemComp, No image

ChemComp-YFH:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / ternary complex / degrader

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